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Some users develop chronic constipation requiring fiber supplementation, increased water intake, or occasional use of osmotic laxatives like polyethylene glycol

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At the age of 42 years she developed an abdominal swelling and was found to have an obstructed incisional hernia for which she had surgery including bowel resection

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72 It has been suggested that this lack of ghrelin suppression may lead to higher food consumption and add to the pathophysiology of obesity